Many reasons to believe that Tuberculosis is an Autoimmune disease – June 2022

Tuberculosis and Autoimmunity

Pathophysiology. 2022 Jun 13;29(2):298-318. doi: 10.3390/pathophysiology29020022.
Irina V Belyaeva 1, Anna N Kosova 1, Andrei G Vasiliev 1

PDF Table of Contents

Tuberculosis remains a common and dangerous chronic bacterial infection worldwide. It is long-established that pathogenesis of many autoimmune diseases is mainly promoted by inadequate immune responses to bacterial agents, among them Mycobacterium tuberculosis. Tuberculosis is a multifaceted process having many different outcomes and complications. Autoimmunity is one of the processes characteristic of tuberculosis; the presence of autoantibodies was documented by a large amount of evidence. The role of autoantibodies in pathogenesis of tuberculosis is not quite clear and widely disputed. They are regarded as:

• (1) a result of imbalanced immune response being reactive in nature,
• (2) a critical part of TB pathogenicity,
• (3) a beginning of autoimmune disease,
• (4) a protective mechanism helping to eliminate microbes and infected cells, and
• (5) playing dual role, pathogenic and protective.

There is no single autoimmunity-mechanism development in tuberculosis; different pathways may be suggested. It may be excessive cell death and insufficient clearance of dead cells, impaired autophagy, enhanced activation of macrophages and dendritic cells, environmental influences such as vitamin D insufficiency, and genetic polymorphism, both of Mycobacterium tuberculosis and host.

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VitaminDWiki - Autoimmune category contains

• 200 items in Autoimmune category
• Vitamin D and   MS    Asthma    RA    Diabetes    Gut   Allergy    Hay Fever    Lupus    Psoriasis
• Predicted 95% autoimmune cured by HIGH-DOSE vitamin D - 2014
• 10% of the UK have Autoimmune Diseases - Lancet May 2023 PDF is behind a paywall
  • Increase in 20 years : coeliac disease 2.19 X. Sjogren's syndrome 2.09, and Graves' disease 2.07
  • All 43 references are FREE on-line
• Autoimmune diseases fought by Vitamin D, especially if have more than 40 ng – Sept 2022
• The BEST Nutrient for Autoimmune Conditions (Vitamin D) - video May 2022
• The number 1 Deficiency behind All Autoimmune Diseases (Vitamin D) video - Dec 2023
• Autoimmune disease clusters run in families having low D
• How Vitamin D reduces inflammation, improves immunity and fights autoimmunity – review Dec 2018
• 120 doctors and 20,000 MS patients using high dose Vitamin D Dec 2018
• Vitamin D has treated Multiple Sclerosis and autoimmune diseases for 16 years – Coimbra April 2018
• Vitamin D Receptor is associated in over 58 autoimmune studies
• More autoimmune disease if higher pollution or lower UVB - Feb 2023
• Many autoimmune diseases associated with low vitamin D or poor Vit D genes – July 2019
  

See also web: consensus that ~50 diseases are autoimmune, ~50 more are suspected:

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VitaminDWiki - Tuberculosis category contains

124 Tuberculosis studies:    15 RCT,   14 Meta-analyses,  8 Vitamin D Receptor

• TB patients had low Vitamin D and poor Vitamin D receptor – June 2019
• Tuberculosis recovery speeded up by single 450,000 IU dose of vitamin D – RCT Jan 2017
  • Receptor-related diseases respond especially well to high-dose Vitamin D
• Pulmonary Tuberculosis 2X more likely if poor Vitamin D Receptor (Mexico) – April 2018
• TB not prevented by a small amount of Vitamin D (2,000 IU daily average, Mongolia) – RCT July 2020
• Tuberculosis -100 percent cure rate with 10,000 IU of vitamin D daily – RCT 2006
• Latent Tuberculosis 44 percent less likely if Vitamin D more than 30 ng - 14th meta-analysis Jan 2022
• Tuberculosis (multi-drug resistant) was 13.4 X more likely to be quickly cleared with Vitamin D - Meta-analysis Feb 2019
• No tuberculosis if more than 80 ng of vitamin D (cattle) - Jan 2022

see also Overview Tuberculosis and Vitamin D    Breathing category
TB has been increasing

VitaminDWiki - Overview Tuberculosis and Vitamin D has

Many studies have found that Vitamin D both PREVENTS and TREATS TB

• As with many other diseases, we expect that there will be at least a 4X range of vitamin D due to:
  • 4X range in the response in the vitamin D blood level for the same IU dose - for healthy, non-obese, people
• Poor Vitamin D Receptor activation results in far less vitamin D getting to cells
  • However, a VDR restriction is not noticed by Vitamin D blood tests
• UV appears to be as powerful or perhaps more powerful than vitamin D in TREATING TB
• Tuberculosis -100 percent cure rate with 10,000 IU of vitamin D daily – RCT 2006
• TB 10X less likely to catch if have sufficient vitamin D – Dec 2011
• Trials using small vitamin D doses neither prevent nor treat TB 2023    2022    2020
• No tuberculosis if more than 80 ng of vitamin D (cattle) - Jan 2022
  • Humans need a lot of Vitamin D as well

TB and vitamin D 124 items